The Philadelphia Eagles travel cross-country to Candelstick Park in San Francisco to take on the 49ers this Sunday night in a game the winless 49ers are surely considering a “must-win.” The oddsmakers have the 49ers (-3.5) as 3.5 point favorites for Sunday night’s matchup against the Eagles.

The 49ers come into this game at 0-4 two weeks after firing their offensive coordinator after Week 3′s loss to the undefeated Kansas City Chiefs at Arrowhead. The 49ers lost a heart-breaker last week to Atlanta in the final seconds, having led the entire game until the last play. They are looking to rebound in a big way at home against a banged up Eagles team, trying desperately to avoid going 0-5. Frank Gore needs to get going early here and give the 9ers passing game some relief, allowing plays to develop down the field.

The Eagles will be without the services of Michael Vick, who’s out with broken rib cartilage. They also may be without running back LeSean McCoy, who’s also nursing a rib injury. Starter turned backup turned starter again Kevin Kolb will be at the helm of the Eagles offense trying to cement his spot as the starter once more. A solid outing here for Kolb will re-ignite the QB controversy in Philly.

49ers backup RB Brian Westbrook also faces his former team for the first time, however Westbrook won’t be on the field much unless Gore has to miss time. The 9ers defense has to be encouraged by their recent play, and if they can get a bit of help from their offense, San Francisco should be able to capitalize and finally break into the Win column.

Here are some matchup trends to consider:

Games played at SAN FRANCISCO over the last 3 seasons.
PHILADELPHIA is 1-0 against the spread versus SAN FRANCISCO over the last 3 seasons
PHILADELPHIA is 1-0 straight up against SAN FRANCISCO over the last 3 seasons
1 of 1 games in this series have gone OVER THE TOTAL over the last 3 seasons

All games in this series since 1992
PHILADELPHIA is 8-4 against the spread versus SAN FRANCISCO since 1992
PHILADELPHIA is 7-5 straight up against SAN FRANCISCO since 1992
7 of 12 games in this series have gone OVER THE TOTAL since 1992

Games over the last 3 seasons
PHILADELPHIA is 2-0 against the spread versus SAN FRANCISCO over the last 3 seasons
PHILADELPHIA is 2-0 straight up against SAN FRANCISCO over the last 3 seasons
1 of 2 games in this series have gone OVER THE TOTAL over the last 3 seasons